The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells
نویسندگان
چکیده
منابع مشابه
The Study of Intracellular Energy in Apoptotic Cells
Khalatbary AR1, Tarihi T2, Naderimanesh H3 1. Assistant Professor, Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences 2. Professor, Department of Anatomy, Faculty of Medicine, Ttarbiat Modarres University , Tehran 3. Professor, Department of Biophysics, Faculty of Basic Sciences, Tarbiat Modarres University , Tehran Abstract Background: Apoptosis is an active ...
متن کاملSemaphorin SEMA3F affects multiple signaling pathways in lung cancer cells.
Loss of SEMA3F occurs frequently in lung cancer and correlates with advanced stage of disease. We previously reported that SEMA3F blocked tumor formation by H157 lung cancer cells in a rat orthotopic model. This was associated with loss of activated alpha(V)beta(3) integrin, impaired cell adhesion to extracellular matrix components, and down-regulation of phospho-extracellular signal-regulated ...
متن کاملSEMA 4 D ( sema domain , immunoglobulin domain ( Ig ) , transmembrane domain ( TM ) and short cytoplasmic domain , ( semaphorin ) 4 D )
Note Semaphorin 4D (Sema4D) was originally identified by Hall., et al. (1996) as a cell surface protein important in B and T lymphocyte activation. Its expression is upregulated in lymphocytes in an immune response (Kumanogoh et al., 2000; Wang et al., 2001). Sema 4D is also expressed in other tissues where it is involved in many motility responses (for review: Artigiani et al., 1999), includin...
متن کاملSemaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Formation of new vessels during development and in the mature mammal generally proceeds through angiogenesis. Although a variety of molecules and signaling pathways are known to underlie endothelial cell sprouting and remodeling during angiogenesis, many aspects of this complex process remain unexplained. Here we show that the transmembrane semaphorin6A (Sema6A) is expressed in endothelial cell...
متن کاملAnticancer and Apoptotic Effects of Ectoine and Hydroxyectoine on Non-Small Cell Lung Cancer cells: An in-vitro Investigation
Introduction: Streptomyces manage the osmotic stress by collecting compatible solutes or osmolytes. Ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid, and 5-hydroxyectoine are among the most common osmolytes of this bacteria and have an active role in protecting the genetic material of this microorganism as well as providing resistance to environmental pressures. In this researc...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2018
ISSN: 2157-9024
DOI: 10.1038/s41389-018-0105-z